Musa Khel District is situated in the northern part of the Khost Province, Afghanistan. It borders with Paktia Province to the north, Sabari District to the east, Khost (Matun) District to the south, Nadir Shah Kot District to the southwest and Qalandar District to the west. The population is 36,300 (2006). The district center is the village of Musa Khel in the northern part of the district.